CAD204520
Product Specifications
UNSPSC Description
CAD204520, a SERCA inhibitor (IC50 = 0.34 μM), targets mutated over wild type NOTCH1 proteins in T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL)[1].
Target Antigen
Calcium Channel; Notch
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling;Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cad204520.html
Smiles
CCCC(C(C=CC(OC(F)(F)F)=C1)=C1N2)=C2C3N(CCN4CCOCC4)CCCC3
Molecular Weight
439.51
References & Citations
[1]Matteo Marchesini, et al. Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia. Cell Chem Biol. 2020 Jun 18;27(6):678-697.e13.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164466/CAD204520-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164466/
Clinical Information
No Development Reported
CAS Number
2682205-20-3
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