ABC99
ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM) . ABC99 preserves Wnt3A signaling in the presence of NOTUM[1].
Product Specifications
CAS Number
[2331255-53-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/abc99.html
Concentration
10mM
Purity
98.48
Solubility
DMSO : 25 mg/mL (ultrasonic; heat to 80°C)
Smiles
O=C(N1C2=CC=CC=C2OCC1)ON(C3=O)C(N4C3CN(CC5=CC=C(Cl)C=C5)CC4)=O
Molecular Formula
C22H21ClN4O5
Molecular Weight
456.88
Precautions
H302, H315, H319
References & Citations
[1]Suciu RM, et al. Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling. ACS Med Chem Lett. 2018;9 (6) :563-568.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Wnt3
Available Sizes
Curated Selection
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