Cefotetan

Cefotetan is a binding agent that targets human Raf1 kinase inhibitor protein (hRKIP) . Cefotetan binds to hRKIP, reduces the binding space between hRKIP and Raf1 kinase, relieves hRKIP's inhibition of the Ras/Raf1/MEK/ERK signaling pathway, and enhances ERK phosphorylation. Cefotetan can be used to study diseases associated with dysregulated Ras/Raf1/MEK/ERK signaling pathways. Cefotetan is also a broad-spectrum antibacterial agent that disrupts cell wall synthesis by binding to bacterial penicillin-binding proteins (PBPs) . It is used to study bacterial infections such as bone, skin, urinary tract, and lower respiratory tract[1][2][3].

Product Specifications

CAS Number

[69712-56-7]

UNSPSC

12352005

Hazard Statement

H317

Target

Antibiotic; Bacterial; ERK; MEK; Raf; Ras

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cefotetan.html

Purity

99.75

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@](OC)(NC(C(S/4)SC4=C(C(O)=O)/C(N)=O)=O)C1=O)O

Molecular Formula

C17H17N7O8S4

Molecular Weight

575.62

Precautions

H317

References & Citations

[1]Guo C, et al. Cefotetan-bound human RKIP involves in Ras/Raf1/MEK/ERK signaling pathway. Acta Biochim Biophys Sin (Shanghai) . 2022 Dec 25;54 (12) :1917-1923.|[2]Phillips I, et al. Cefotetan: in-vitro antibacterial activity and susceptibility to beta-lactamases. J Antimicrob Chemother. 1983 Jan;11 Suppl:1-9.|[3]Komiya M. et al. Absorption, distribution, metabolism, and excretion of cefotetan (YM09330) in experimental animals[J]. Chemotherapy, 1982, 30 (Supplement1) : 106-118.