AGN 205728
Product Specifications
UNSPSC Description
AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.
IC50 value: 3 nM/ 0.6 nM(Ki/IC95)
Target: RARγ antagonist
More information can be found in the following patent, Compound 7a.
Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity
By Tsang, Kwok Yin; Sinha, Santosh; Liu, Xiaoxia; Bhat, Smita; Chandraratna, Roshantha A.
From PCT Int. Appl. (2005), WO 2005066115 A2 20050721.
Target Antigen
Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Autophagy;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AGN-205728.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C=C1)=CC=C1C2=CCC(C)(C)C3=C2C=CC(C(/C=C/C4=CC=C(C(O)=O)C=C4)=N/O)=C3
Molecular Weight
437.53
References & Citations
[1]Tsang, Kwok Yin, et al. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity. Appl. (2005), WO 2005066115 A2 20050721.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16683/AGN-205728-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16683/AGN-205728-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
859498-05-8
Available Sizes
Curated Selection
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