AGN 205728

AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/0.6 nM; no inhibiton on RARα and RARβ. AGN 205728 can inhibit abnormal proliferation of leukemia cells[1][2].

Product Specifications

CAS Number

[859498-05-8]

UNSPSC

12352005

Target

Autophagy; RAR/RXR

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AGN-205728.html

Purity

98.62

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C=C1)=CC=C1C2=CCC(C)(C)C3=C2C=CC(C(/C=C/C4=CC=C(C(O)=O)C=C4)=N/O)=C3

Molecular Formula

C29H27NO3

Molecular Weight

437.53

References & Citations

[1]Tsang, Kwok Yin, et al. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity. Appl. (2005), WO 2005066115 A2 20050721.|[2]Watts JM, et al. A Case of AML Characterized by a Novel t (4;15) (q31; q22) Translocation That Confers a Growth-Stimulatory Response to Retinoid-Based Therapy. Int J Mol Sci. 2017 Jul 11;18 (7) :1492.