SC209

SC209 (3-Aminophenyl Hemiasterlin) is a 3-aminophenyl hemiasterlin derivative that serves as a cytotoxin for ADCs, targeting tubulin. SC209 has reduced potential for drug efflux via P-glycoprotein 1 drug pump compared with other tubulin-targeting payloads. SC209 exhibits antitumor activity and can be used in the synthesis of ADC molecules[1][2].

Product Specifications

CAS Number

[1977557-86-0]

Product Name Alternative

3-Aminophenyl Hemiasterlin

UNSPSC

12352203

Target

ADC Payload; Microtubule/Tubulin; P-glycoprotein

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sc209.html

Purity

99.52

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC(/C(C)=C/[C@H](C(C)C)N(C)C([C@H](C(C)(C)C)NC([C@@H](NC)C(C)(C1=CC(N)=CC=C1)C)=O)=O)=O

Molecular Formula

C27H44N4O4

Molecular Weight

488.66

References & Citations

[1]Alice Yam, et al. Bispecific antibody-drug conjugates targeting egfr and muc1 and uses thereof. Patent. WO2021247798. 2021-12-09.|[2]De Almeida V, et al. Preclinical activity and safety of STRO-002, a novel ADC targeting folate receptor alpha for ovarian cancer. Gynecologic Oncology, 2018, 149: 50.