ATPA

ATPA is a selective glutamate receptor GluR5 activator with EC50s of 0.66, 9.5, 1.4, 23, 32, 18, and 14 μM for GluR5wt, GluR5 (S741M), GluR5 (S721T), GluR5 (S721T, S741M), GluR5 (S741A), GluR5 (S741L), and GluR5 (S741V), respectively[1].

Product Specifications

CAS Number

[140158-50-5]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/atpa.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(O)C(N)CC1=C(C(C)(C)C)ONC1=O

Molecular Formula

C10H16N2O4

Molecular Weight

228.25

References & Citations

[1]Nielsen MM, et al. The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741. Mol Pharmacol. 2003 Jan;63 (1) :19-25.