Albendazole

Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells[1][2][3][4][5].

Product Specifications

CAS Number

[54965-21-8]

Product Name Alternative

SKF-62979

UNSPSC

12352005

Hazard Statement

H361, H373, H410

Target

Antibiotic; Apoptosis; Autophagy; Bacterial; HIF/HIF Prolyl-Hydroxylase; Microtubule/Tubulin; Parasite; Reactive Oxygen Species (ROS) ; VEGFR

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Albendazole.html

Concentration

10mM

Purity

99.05

Solubility

DMSO : 20 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(OC)NC1=NC2=CC=C(SCCC)C=C2N1

Molecular Formula

C12H15N3O2S

Molecular Weight

265.33

Precautions

H361, H373, H410

References & Citations

[1]Vural G, et al. Efficacy of novel albendazole salt formulations against secondary cystic echinococcosis in experimentally infected mice. Parasitology. 2020 Nov;147 (13) :1425-1432.|[2]Li L, et al. Determination of albendazole and metabolites in silkworm Bombyx mori hemolymph by ultrafast liquid chromatography tandem triple quadrupole mass spectrometry. PLoS One. 2014 Sep 25;9 (9) :e105637.|[3]Pourgholami MH, et al. In vitro and in vivo suppression of growth of hepatocellular carcinoma cells by albendazole. Cancer Lett. 2001 Apr 10;165 (1) :43-9.|[4]Jung YY, et al. Regulation of apoptosis and autophagy by albendazole in human colon adenocarcinoma cells. Biochimie. 2022 Jul;198:155-166.|[5]Zhou F, et al. Albendazole inhibits HIF-1α-dependent glycolysis and VEGF expression in non-small cell lung cancer cells. Mol Cell Biochem. 2017 Apr;428 (1-2) :171-178.