Verazine

Verazine ((-) -Verazine) is an anti-Fungal Agent that can be found in the dried roots and rhizoma of Veratrum maackii Regel. Verazine causes DNA damage in the cerebellum and cerebral cortex of mice in a dose-dependent manner. Verazine can be used in the study of fungal infections and neurological diseases[1][2].

Product Specifications

CAS Number

[14320-81-1]

Product Name Alternative

(-) -Verazine

UNSPSC

12352005

Target

Fungal

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/verazine.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

C[C@]12[C@](CC[C@]1([H])[C@@H](C(CC3)=NC[C@H]3C)C)([H])[C@@](CC=C4C[C@H]5O)([H])[C@@](CC2)([H])[C@]4(CC5)C

Molecular Formula

C27H43NO

Molecular Weight

397.64

References & Citations

[1]Cong Y, et al. Steroidal Alkaloids from Veratrum maackii Regel with Genotoxicity on Brain-Cell DNA in Mice. Helv Chim Acta. 2015, 98 (4) : 539-545.|[2]Augustin MM, et al. Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells. Plant J. 2015 Jun;82 (6) :991-1003.