L-655708
L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki=0.45 nM) .
Product Specifications
CAS Number
[130477-52-0]
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/L-655708.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=CC=C(C2=C1)N3C=NC(C(OCC)=O)=C3[C@@]4([H])N(CCC4)C2=O
Molecular Formula
C18H19N3O4
Molecular Weight
341.36
References & Citations
[1]Saab BJ, et al. Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptorinverse agonist L-655708. Anesthesiology. 2010 Nov;113 (5) :1061-1071.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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