Schisandrin

Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats[1][2][3].

Product Specifications

CAS Number

[7432-28-2]

Product Name Alternative

Schizandrin; Schizandrol; Schizandrol-A

UNSPSC

12352005

Hazard Statement

H302, H400

Target

Autophagy

Type

Natural Products

Related Pathways

Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Schisandrin.html

Purity

99.97

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O[C@]1(C)[C@@H](C)CC2=CC(OC)=C(OC)C(OC)=C2C3=C(OC)C(OC)=C(OC)C=C3C1

Molecular Formula

C24H32O7

Molecular Weight

432.51

Precautions

H302, H400

References & Citations

[1]Guo LY, et, al. Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. Eur J Pharmacol. 2008 Sep 4;591 (1-3) :293-9.|[2]Egashira N, et, al. Schizandrin reverses memory impairment in rats. Phytother Res. 2008 Jan;22 (1) :49-52.|[3]Min HY, et, al. Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells. Bioorg Med Chem Lett. 2008 Jan 15;18 (2) :523-6.|[4]Zhang ZL, et, al. Schisandrin A reverses doxorubicin-resistant human breast cancer cell line by the inhibition of P65 and Stat3 phosphorylation. Breast Cancer. 2018 Mar;25 (2) :233-242.