1,4-Cineole

1,4-Cineole is an oxygenated monoterpene found in eucalyptus oil. 1,4-Cineole is a hTRPM8 and hTRPA1 agonist. 1,4-Cineole can increase intracellular Ca2+ concentration. 1,4-Cineole exhibits anti-anxiety and anti-depression effects. 1,4-Cineole can be used for the research of neurological disease, such as depression [1][2].

Product Specifications

CAS Number

[470-67-7]

UNSPSC

12352005

Hazard Statement

H225, H303

Target

TRP Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1-4-cineole.html

Purity

95.0

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(C12CCC(O2)(C)CC1)C

Molecular Formula

C10H18O

Molecular Weight

154.25

Precautions

H225, H303

References & Citations

[1]Takaishi M, et al. 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1. Mol Pain. 2012 Nov 29;8:86.|[2]Dougnon G, et al. Inhalation Administration of the Bicyclic Ethers 1,8- and 1,4-cineole Prevent Anxiety and Depressive-Like Behaviours in Mice. Molecules. 2020 Apr 18;25 (8) :1884.