EAAT2 activator 1

EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2) . EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently[1].

Product Specifications

CAS Number

[892415-28-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

EAAT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/eaat2-activator-1.html

Purity

98.91

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=CC=CC(Cl)=C1CSC2=CC=C(C3=NC=CC=C3)N=N2

Molecular Formula

C16H11ClFN3S

Molecular Weight

331.80

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Xing X, et al. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett. 2011;21 (19) :5774-5777.