S29434
S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production[1].
Product Specifications
CAS Number
[874484-20-5]
Product Name Alternative
NMDPEF
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s29434.html
Purity
99.29
Solubility
DMSO : 19.29 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CO1)NCCC2=C(C3=NC=CC=C3C4)N4C5=CC=C(OC)N=C52
Molecular Formula
C21H18N4O3
Molecular Weight
374.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Boutin JA, et al. S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization. Mol Pharmacol. 2019 Mar;95 (3) :269-285.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Recombinant Arabidopsis thaliana Heat stress transcription factor A-6a (HSFA6A)
Recombinant Arabidopsis thaliana Heat stress transcription factor A-6a (HSFA6A)
Recombinant Arabidopsis thaliana Heat stress transcription factor A-6a (HSFA6A)
Recombinant Arabidopsis thaliana Heat stress transcription factor A-6a (HSFA6A)