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Ro 25-1553

Ro 25-1553 is a 31 amino acid vasoactive intestinal peptide (VIP) analog, that acts as an agonist for VIP2 receptor (VPAC2 receptor) . Ro 25-1553 exhibits a bronchodilator effect in nerve-induced or Carbachol (HY-B1208) -induced tracheal smooth muscle contraction in guinea pig model[1].

Product Specifications

CAS Number

[159427-08-4]

UNSPSC

12352209

Target

PACAP Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ro-25-1553.html

Smiles

O=C([C@H](CCCCNC(C[C@H](NC([C@@H](NC([C@@H](NC1=O)CC(C)C)=O)CC(N)=O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(NCC(NCC(N[C@H](C(N)=O)[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C)NC([C@H](CCCC)NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CCC(O)=O)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@@H](NC(C)=O)CC2=CN=CN2)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N[C@H]1CC5=CC=C(C=C5)O

Molecular Formula

C160H258N46O46

Molecular Weight

3562.04

References & Citations

[1]Källström BL, et al., Bronchodilating properties of the VIP receptor agonist Ro 25-1553 compared to those of formoterol on the guinea-pig isolated trachea. Eur J Pharmacol. 2001 Nov 2;430 (2-3) :335-40.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P10768/Ro-25-1553-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P10768/

Scientific Category

Peptides

Clinical Information

No Development Reported

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