Hesperetin-d3

Hesperetin-d3 is the deuterium labeled Hesperetin[1]. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis[2][3].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Autophagy; p38 MAPK

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Autophagy; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C1C[C@@H](C2=CC=C(OC([2H])([2H])[2H])C(O)=C2)OC3=CC(O)=CC(O)=C13

Molecular Formula

C16H11D3O6

Molecular Weight

305.30

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Liu D, et al. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions. Biol Pharm Bull. 2016;39 (12) :2052-2059.|[3]Shagirtha K, et al. Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. Toxicol Ind Health. 2016 Nov 1. pii: 0748233716665301.