7-Ketocholesterol
Product Specifications
Product Name Alternative
CI-636,Clodantoin,Xenazoic acid; CV58911
UNSPSC Description
7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis)[1].
Target Antigen
Endogenous Metabolite; p38 MAPK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway;Metabolic Enzyme/Protease
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/7-ketocholesterol.html
Purity
99.87
Solubility
DMSO : 6.25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
C[C@]1(CC2)[C@](CC[C@]1([H])[C@H](C)CCCC(C)C)([H])[C@@](C(C=C3C[C@H]4O)=O)([H])[C@@]2([H])[C@]3(CC4)C
Molecular Weight
400.64
References & Citations
[1]M A Lyons, et al. 7-Ketocholesterol. Int J Biochem Cell Biol. Mar-Apr 1999;31(3-4):369-75. |[2]Amelia Anderson, et al. 7-Ketocholesterol in disease and aging. Redox Biol. 2020 Jan;29:101380.|[3]Amaral J, et al. 7-Ketocholesterol induces inflammation and angiogenesis in vivo: a novel rat model. PLoS One. 2013;8(2):e56099.|[4]Tani M, et al. 7-Ketocholesterol enhances leukocyte adhesion to endothelial cells via p38MAPK pathway. PLoS One. 2018 Jul 31;13(7):e0200499.|[5]Luthra S, et al. 7-Ketocholesterol activates caspases-3/7,-8, and-12 in human microvascular endothelial cells in vitro[J]. Microvascular research, 2008, 75(3): 343-350.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113342/7-Ketocholesterol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113342/7-Ketocholesterol-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
566-28-9
Available Sizes
Curated Selection
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