Sematilide (hydrochloride)

Product Specifications

UNSPSC Description

Sematilide hydrochloride (CK-1752 hydrochloride) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent[1].

Target Antigen

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sematilide-hydrochloride.html

Purity

99.33

Solubility

DMSO : 1.67 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

O=C(NCCN(CC)CC)C1=CC=C(NS(=O)(C)=O)C=C1.Cl

Molecular Weight

349.88

References & Citations

[1]Ishii Y, et al. Effects of Sematilide, a novel class III antiarrhythmic agent, on membrane currents in rabbit atrial myocytes. Eur J Pharmacol. 1997 Jul 23;331(2-3):295-302.|[2]Stanley S. Greenberg, et al. Pharmacology of Sematilide, a non-quaternary class III antiarrhythmic agent.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-101436A/Sematilide-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-101436A/Sematilide-hydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

101526-62-9

Available Sizes

Curated Selection

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