Veratramine

Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a SIGMAR1 modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT) -related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy[1][2][3][4].

Product Specifications

CAS Number

[60-70-8]

Product Name Alternative

NSC17821; NSC23880

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; Apoptosis; Autophagy; mTOR; PI3K

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Veratramine.html

Purity

99.84

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O[C@H]1[C@H]([C@H](C2=C(C)C3=C(C=C2)[C@]4([H])CC=C(C[C@@H](O)CC5)[C@@]5(C)[C@@]4([H])C3)C)NC[C@@H](C)C1

Molecular Formula

C27H39NO2

Molecular Weight

409.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Yin L, et al. Veratramine suppresses human HepG2 liver cancer cell growth in vitro and in vivo by inducing autophagic cell death. Oncol Rep. 2020 Aug;44 (2) :477-486.|[2]Xie Z, et al. Veratramine influences the proliferation of human osteosarcoma cells through modulation of the PI3K/AKT signaling cascade. Genes & Diseases, 2025: 101630.|[3]Zhang Y, et al. Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway. Pharm Biol. 2022 Dec;60 (1) :2145-2154.|[4]Wang L, et al. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. Pharmazie. 2008 Aug;63 (8) :606-10.