DSRM-3716

DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection[1].

Product Specifications

CAS Number

[58142-99-7]

Product Name Alternative

5-Iodoisoquinoline

UNSPSC

12352005

Hazard Statement

H302, H311, H315, H319, H402, H412

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dsrm-3716.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

IC1=CC=CC2=C1C=CN=C2

Molecular Formula

C9H6IN

Molecular Weight

255.06

Precautions

H302, H311, H315, H319, H402, H412

References & Citations

[1]Robert O Hughes, et al. Small Molecule SARM1 Inhibitors Recapitulate the SARM1 -/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate. Cell Rep. 2021 Jan 5;34 (1) :108588.