Lactupicrin

Lactupicrin (Lactucopicrin) exhibits analgesic, sedative, antimalarial activities and atheroprotective effect. Lactupicrin inhibits acetylcholinesterase (AChE) with an IC50 of 150.3 μM. Lactupicrin is an orally active characteristic bitter sesquiterpene lactone[1][2][3][4][5].

Product Specifications

CAS Number

[65725-11-3]

Product Name Alternative

Lactucopicrin

UNSPSC

12352005

Hazard Statement

H317

Target

Cholinesterase (ChE) ; LOX-1; NF-κB; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/lactupicrin.html

Purity

99.97

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OCC([C@](C1=C2C)([H])[C@](OC3=O)([H])[C@@](C3=C)([H])[C@H](C2)OC(CC(C=C4)=CC=C4O)=O)=CC1=O

Molecular Formula

C23H22O7

Molecular Weight

410.42

Precautions

H317

References & Citations

[1]Wesołowska A, et, al. Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice. J Ethnopharmacol. 2006 Sep 19;107 (2) :254-8.|[2]Li Q, et, al. Terpene Lactucopicrin Limits Macrophage Foam Cell Formation by a Reduction of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Lipid Rafts. Mol Nutr Food Res. 2022 Feb;66 (4) :e2100905. |[3]He L, et al. Lactupicrin Inhibits Cytoplasmic Dynein-Mediated NF-κB Activation in Inflammated Macrophages and Alleviates Atherogenesis in Apolipoprotein E-Deficient Mice. Mol Nutr Food Res. 2021 Feb;65 (4) :e2000989. |[4] Bischoff TA, et al. Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L. J Ethnopharmacol. 2004 Dec;95 (2-3) :455-7. |[5]Rollinger JM, et al. Application of the in combo screening approach for the discovery of non-alkaloid acetylcholinesterase inhibitors from Cichorium intybus. Curr Drug Discov Technol. 2005 Sep;2 (3) :185-93.