Trazodone

Trazodone (AF-1161 free base) is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs) . Trazodone has anti-depressant and anti-insomnious activity. Trazodone exerts antagonistic properties against a1- and a2-adrenergic receptors and histamine H1 receptors, with minimal anticholinergic effects[1].

Product Specifications

CAS Number

[19794-93-5]

Product Name Alternative

AF-1161 (free base)

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

5-HT Receptor; Adrenergic Receptor; Histamine Receptor; Serotonin Transporter

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/trazodone.html

Concentration

10mM

Purity

99.84

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C4C=CC=CN41

Molecular Formula

C19H22ClN5O

Molecular Weight

371.86

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Fagiolini A, et, al. Rediscovering trazodone for the treatment of major depressive disorder. CNS Drugs. 2012 Dec;26 (12) :1033-49.|[2]Brogden, R. N., et al., (1981) . Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs, 21 (6), 401–429.|[3]Raffa, R. B., et al., (1992) . Etoperidone, trazodone and MCPP: in vitro and in vivo identification of serotonin 5-HT1A (antagonistic) activity. Psychopharmacology, 108 (3), 320–326.|[4]Ghanbari, R., et al., (2010) . Sustained administration of trazodone enhances serotonergic neurotransmission: in vivo electrophysiological study in the rat brain. The Journal of pharmacology and experimental therapeutics, 335 (1), 197–206.|[5]Jay AR, Krotscheck U, Parsley E, Benson L, Kravitz A, Mulligan A, Silva J, Mohammed H, Schwark WS. Pharmacokinetics, bioavailability, and hemodynamic effects of trazodone after intravenous and oral administration of a single dose to dogs. Am J Vet Res. 2013 Nov;74 (11) :1450-6.|[6]Daniele S, et al. Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK. Cell Signal. 2015 Aug;27 (8) :1609-29.