Utidelone

Utidelone (Epothilone D) is a potent microtubule stabilizer.

Product Specifications

CAS Number

[189453-10-9]

Product Name Alternative

Epothilone D; UTD1; KOS 862

UNSPSC

12352005

Target

Antibiotic; Bacterial; Fungal; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Epothilone-D.html

Purity

99.93

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1C[C@H](O)C(C)(C)C([C@H](C)[C@@H](O)[C@@H](C)CCC/C(C)=C/C[C@@H](/C(C)=C/C2=CSC(C)=N2)O1)=O

Molecular Formula

C27H41NO5S

Molecular Weight

491.68

References & Citations

[1]Konner J, et al. Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma. Invest New Drugs. 2012 Dec;30 (6) :2294-302.|[2]Brunden KR, et al. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. J Neurosci. 2010 Oct 13;30 (41) :13861-6.