Utidelone
Utidelone (Epothilone D) is a potent microtubule stabilizer.
Product Specifications
CAS Number
[189453-10-9]
Product Name Alternative
Epothilone D; UTD1; KOS 862
UNSPSC
12352005
Target
Antibiotic; Bacterial; Fungal; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Epothilone-D.html
Purity
99.93
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C[C@H](O)C(C)(C)C([C@H](C)[C@@H](O)[C@@H](C)CCC/C(C)=C/C[C@@H](/C(C)=C/C2=CSC(C)=N2)O1)=O
Molecular Formula
C27H41NO5S
Molecular Weight
491.68
References & Citations
[1]Konner J, et al. Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma.
 Invest New Drugs. 2012 Dec;30 (6) :2294-302.|[2]Brunden KR, et al. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.
 J Neurosci. 2010 Oct 13;30 (41) :13861-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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