Epothilone D
Product Specifications
UNSPSC Description
Epothilone D (KOS 862) is a potent microtubule stabilizer.
Target Antigen
Antibiotic; Bacterial; Fungal; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Anti-infection;Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Epothilone-D.html
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(O[C@@H](C/C=C(CCC[C@@H]([C@@H]([C@H](C1=O)C)O)C)/C)/C(C)=C/C2=CSC(C)=N2)C[C@@H](C1(C)C)O
Molecular Weight
491.68
References & Citations
[1]Konner J, et al. Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma.
 Invest New Drugs. 2012 Dec;30(6):2294-302.|[2]Brunden KR, et al. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.
 J Neurosci. 2010 Oct 13;30(41):13861-6.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15278/Epothilone-D-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15278/Epothilone-D-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
189453-10-9
Available Sizes
Curated Selection
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