Laroprovstat

Laroprovstat (AZD0780) is an orall active PCSK9 inhibitor. PCSK9-IN-12 has bind affinity for PCSK9 with a Kd value of [1][2].

Product Specifications

CAS Number

[2455427-91-3]

Product Name Alternative

AZD0780; PCSK9-IN-12

UNSPSC

12352005

Target

PCSK9

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/azd0780.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C=CC=C1)C2=CN=C(N[C@@H]3C[C@H](CC3)NC4=NC=C(OC(F)F)C=N4)C=C2

Molecular Formula

C20H20F2N6O2

Molecular Weight

414.41

References & Citations

[1]Michael H. Serrano-Wu, et al. Pcsk9 inhibitors and methods of use thereof. Patent. WO2020150474A1.|[2]Koren MJ, et al. An Oral PCSK9 Inhibitor for Treatment of Hypercholesterolemia: The PURSUIT Randomized Trial. J Am Coll Cardiol. 2025 Jun 3;85 (21) :1996-2007.