Rivenprost

Rivenprost (ONO-4819; ONO-AE1-734) is a selective agonist for prostaglandin E receptor EP4 with Ki of 0.7 nM. Rivenprost exhibits hepatoprotective and bone anabolic effects[1][2].

Product Specifications

CAS Number

[256382-08-8]

Product Name Alternative

ONO-4819; ONO-AE1-734

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Others

Assay Protocol

https://www.medchemexpress.com/rivenprost.html

Concentration

2.22 mM * 500 μL in Methyl acetate

Purity

99.0

Solubility

10 mM in DMSO

Smiles

COCC1=CC=CC(C[C@H](O)/C=C/[C@@H]2[C@H](C(C[C@H]2O)=O)CCSCCCC(OC)=O)=C1

Molecular Formula

C24H34O6S

Molecular Weight

450.59

Precautions

H302, H315, H319, H335

References & Citations

[1]Ninomiya T, et al., Prostaglandin E (2) receptor EP (4) -selective agonist (ONO-4819) increases bone formation by modulating mesenchymal cell differentiation. Eur J Pharmacol. 2011 Jan 10;650 (1) :396-402.|[2]Kasai K, et al., A novel prostaglandin E receptor subtype agonist, 0N0-4819, attenuates acute experimental liver injury in rats. Hepatol Res. 2001 Nov;21 (3) :252-260.