HDM-IN-1

HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC50s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC80 of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model[1].

Product Specifications

CAS Number

[3020690-76-7]

UNSPSC

12352005

Target

Fungal; Histone Demethylase

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hdm-in-1.html

Smiles

COC(C=C1)=CN=C1N/N=C(C2=NC=CC=C2)\C3=NC=CC=C3

Molecular Formula

C17H15N5O

Molecular Weight

305.33

References & Citations

[1]Liu X, et al., Discovery of new fungal jumonji H3K27 demethylase inhibitors for the treatment of Cryptococcus neoformans and Candida auris infections. Eur J Med Chem. 2025 Jan 5;281:117028.