PROTAC PD-L1 degrader-1
Product Specifications
UNSPSC Description
PROTAC PD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with a notable PD-L1 protein degradation capability. PROTAC PD-L1 degrader-1 shows potent PD-L1 degradation in 4T1 cells with a DC50 of 0.609 μM. PROTAC PD-L1 degrader-1 can be used for the study of breast cancer. (Blue: CRBN ligand (HY-150839), Black: linker; Pink: PD-L inhibitor (HY-19745))[1].
Target Antigen
PD-1/PD-L1; PROTACs
Type
Reference compound
Related Pathways
Immunology/Inflammation;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/protac-pd-l1-degrader-1.html
Smiles
O=C(NCCNCC1=CC=C(OCC2=C(C)C(C3=CC=CC=C3)=CC=C2)N=C1OC)CCCCCCCCNC(COC4=CC=C(C(CC5)C(NC5=O)=O)C=C4)=O
Molecular Weight
777.95
References & Citations
[1]Hongjia Zhang, et al. Discovery of Novel Proteolysis-Targeting Chimera Molecules as Degraders of Programmed Cell Death-Ligand 1 for Breast Cancer Therapy. J Med Chem. 2024 Jun 18.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163757/PROTAC-PD-L1-degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163757/
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Clinical Information
No Development Reported
Curated Selection
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