Neoandrographolide

Neoandrographolide is a diterpenoid compound isolated from Andrographis paniculata. Neoandrographolide inhibits osteoclasts differentiation and bone resorption through inhibition of MAPK/NF-κB/PI3K/AKT/GSK3β/PPAR/CAMK signaling pathway. Neoandrographolide inhibits apoptosis in rat embryonic ventricular cardiomyocytes. Neoandrographolide inhibits iNOS and the generation of ROS, activates eNOS, exhibiting anti-inflammatory and hypolipidemic activity[1][2][3][4][5].

Product Specifications

CAS Number

[27215-14-1]

Product Name Alternative

Neoandrographiside

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; CaMK; ERK; GSK-3; JNK; NF-κB; NO Synthase; p38 MAPK; PI3K; PPAR; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Neoandrographolide.html

Purity

99.41

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]([C@@H]1CCC2=CCOC2=O)(CCC3)[C@@](CCC1=C)([H])[C@]3(C)CO[C@@H]([C@@H]([C@@H](O)[C@@H]4O)O)O[C@@H]4CO

Molecular Formula

C26H40O8

Molecular Weight

480.59

Precautions

H302, H315, H319, H335

References & Citations

[1]Tao Yang, et al. Hypolipidemic Effects of Andrographolide and Neoandrographolide in Mice and Rats. Phytotherapy Research Volume 27, Issue 4, pages 618–623, April 2013|[2]Tang K, et al., Neoandrographolide inhibits mature osteoclast differentiation to alleviate bone loss and treat osteoporosis. Front Pharmacol. 2025 Feb 11;16:1466057.|[3]Liu Y, et al., Amelioratory effect of neoandrographolide on myocardial ischemic-reperfusion injury by its anti-inflammatory and anti-apoptotic activities. Environ Toxicol. 2021 Dec;36 (12) :2367-2379.|[4]Liu J, et al., In vivo and in vitro anti-inflammatory activities of neoandrographolide. Am J Chin Med. 2007;35 (2) :317-28.|[5]Yang T, et al., Hypolipidemic effects of andrographolide and neoandrographolide in mice and rats. Phytother Res. 2013 Apr;27 (4) :618-23.