Neutrophil elastase inhibitor 3
Product Specifications
UNSPSC Description
Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and exhibits as a neutrophil elastase (NE) inhibitor, with an IC50 of 80.8 nM for NE release[1].
Target Antigen
Elastase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/neutrophil-elastase-inhibitor-3.html
Solubility
10 mM in DMSO
Smiles
O=C1OC(C2=CC=CC=C2Br)=NC3=CC=CC(Cl)=C13
Molecular Weight
336.57
References & Citations
[1]Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats. Eur J Med Chem. 2010 Jul;45(7):3111-5.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-132132/Neutrophil-elastase-inhibitor-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-132132/
Clinical Information
No Development Reported
CAS Number
1234707-32-4
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