Niloticin

Niloticin, tetracyclic triterpenoid compound, is a osteoclastogenesis inhibitor. Niloticin shows anti-viral, antioxidative, and mosquitocidal activities. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways[1].

Product Specifications

CAS Number

[115404-57-4]

UNSPSC

12352005

Target

Akt; NF-κB

Type

Natural Products

Related Pathways

NF-κB; PI3K/Akt/mTOR

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/niloticin.html

Purity

98.0

Solubility

Acetone : ≥ 25 mg/mL

Smiles

C[C@@]1(CC[C@@]2([H])[C@@H](C)C[C@H]([C@@](O3)([H])C3(C)C)O)C([C@]4([H])CC[C@]12C)=CC[C@](C(C)5C)([H])[C@@]4(CCC5=O)C

Molecular Formula

C30H48O3

Molecular Weight

456.70

References & Citations

[1]Xu H, et al. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways. Biomed Pharmacother. 2022 May;149:112902.