PHTPP-1304

PHTPP-1304 is a PHTPP-based autophagy targeting chimera (AUTOTAC) . PHTPP-1304 induces the degradation of estrogen receptor ERβ through the autophagy pathway, rather than ubiquitination (DC50 ≈ 2 nM, in HEK293T cells; p62. PHTPP-1304 can be used to study various cancers mediated by ERβ[1].

Product Specifications

CAS Number

[2410081-60-4]

UNSPSC

12352005

Target

Autophagy; AUTOTACs; Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Autophagy; PROTAC; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/phtpp-1304.html

Purity

99.96

Solubility

DMSO : 110 mg/mL (ultrasonic)

Smiles

O[C@H](CNCCOCCOCCOC1=CC=C(C2=C3N(C(C(F)(F)F)=CC(C(F)(F)F)=N3)N=C2C4=CC=CC=C4)C=C1)COC5=CC(OCCCC6=CC=CC=C6)=C(OCC7=CC=CC=C7)C=C5

Molecular Formula

C51H50F6N4O7

Molecular Weight

944.96

References & Citations

[1]Ji CH, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904. doi: 10.1038/s41467-022-28520-4. Erratum in: Nat Commun. 2022 Apr 12;13 (1) :2108.