PHTPP-1304
Product Specifications
UNSPSC Description
PHTPP-1304 is a PHTPP-based autophagy targeting chimera (AUTOTAC) that induces p62 self-oligomerization and degradation of estrogen receptor ERβ (DC50:~2 nM, HEK293T). PHTPP-1304 also induces the formation of p62+ERβ+ puncta that are affected by autophagic flux in a dose-dependent manner[1].
Target Antigen
Autophagy; AUTOTACs; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Autophagy;PROTAC;Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/phtpp-1304.html
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
O[C@H](CNCCOCCOCCOC1=CC=C(C2=C3N(C(C(F)(F)F)=CC(C(F)(F)F)=N3)N=C2C4=CC=CC=C4)C=C1)COC5=CC(OCCCC6=CC=CC=C6)=C(OCC7=CC=CC=C7)C=C5
Molecular Weight
944.96
References & Citations
[1]Ji CH, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13(1):904. doi: 10.1038/s41467-022-28520-4. Erratum in: Nat Commun. 2022 Apr 12;13(1):2108.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161740/PHTPP-1304-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161740/PHTPP-1304-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2410081-60-4
Available Sizes
Curated Selection
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