PROTAC KSP-IN-1
Product Specifications
UNSPSC Description
PROTAC KSP-IN-1 (Compound 21) is a PROTAC Degrader for kinesin spindle protein (KSP), that degrades KSP in HCT-116 with DC50 of 114.8 nM. PROTAC KSP-IN-1 inhibits the proliferation of HCT-116 with IC50 of 10 nM, arrests the cell cycle of HCT-116 at G2/M phase, and induces apoptosis in HCT-116. PROTAC KSP-IN-1 exhibits antitumor efficacy in mouse model[1]. (Blue: Ligand for E3 Ligase Cereblon (HY-103596); Blank: Linker (HY-168726); Pink: Target Protein Ligand (HY-168727))
Target Antigen
Apoptosis; Kinesin; PROTACs
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-ksp-in-1.html
Smiles
O=C(NCCCCCCCCNC(COC1=C2C(C(N(C3CCC(NC3=O)=O)C2=O)=O)=CC=C1)=O)[C@@H](N)CSC4(C5=CC=C(OC)C=C5)C6=CC=CC=C6C=CC7=C4C=CC=C7
Molecular Weight
858.01
References & Citations
[1]Zhao DG, et al., Discovery of novel KSP-targeting PROTACs with potent antitumor effects in vitro and in vivo. Eur J Med Chem. 2025 Jan 15;282:117052.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168725/PROTAC-KSP-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168725/
Clinical Information
No Development Reported
Curated Selection
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