Adefovir

Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].

Product Specifications

CAS Number

[106941-25-7]

Product Name Alternative

GS-0393; PMEA

UNSPSC

12352005

Hazard Statement

H301

Target

HBV; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection

Applications

Neuroscience-Neuromodulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/adefovir.html

Purity

99.74

Solubility

0.1 M NaOH : 10 mg/mL (ultrasonic; adjust pH to 10 with NaOH) |DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=C2N=CN(CCOCP(O)(O)=O)C2=NC=N1

Molecular Formula

C8H12N5O4P

Molecular Weight

273.19

Precautions

H301

References & Citations

[1]X.-X.Zhou, et al. 7.11 - Deoxyribonucleic Acid Viruses: Antivirals for Herpesviruses and Hepatitis B Virus. Comprehensive Medicinal Chemistry II. Volume 7, 2007, Pages 295-327.|[2]Marcellin P, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med. 2003 Feb 27;348 (9) :808-16.|[3]Leah A.Burke, et al. 155 - Drugs to Treat Viral Hepatitis. Infectious Diseases. Volume 2, 2017, Pages 1327-1332.