Monascuspiloin
Product Specifications
UNSPSC Description
Monascuspiloin (Monascinol) exhibits anti-androgenic activity with an IC50 of 7 μM. Monascuspiloin inhibits viability of PC-3 and LNCaP with IC50 of 45 and 47 μM. Monascuspiloin induces apoptosis in LNCaP through inhibition of Akt/mTOR signaling pathway, induces autophagy through activation AMPK signaling pathway and arrest cell cycle at G2/M phase in PC-3. Monascuspiloin exhibits antitumor efficacy in mice[1][2].
Target Antigen
Akt; AMPK; Androgen Receptor; Apoptosis; Autophagy; mTOR
Type
Natural Products
Related Pathways
Apoptosis;Autophagy;Epigenetics;PI3K/Akt/mTOR;Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/monascuspiloin.html
Smiles
C[C@]12[C@@](CC3=C(COC(/C=C/C)=C3)C2=O)([H])[C@H](C(O1)=O)[C@@H](O)CCCCC
Molecular Weight
360.44
References & Citations
[1]Chen RJ, et al., Monascuspiloin induces apoptosis and autophagic cell death in human prostate cancer cells via the Akt and AMPK signaling pathways. J Agric Food Chem. 2012 Jul 25;60(29):7185-93. |[2]Chiu HW, et al., Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagy. PLoS One. 2012;7(7):e40462.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N12124/Monascuspiloin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N12124/
Clinical Information
No Development Reported
CAS Number
1011244-19-1
Curated Selection
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