AZD 9272

AZD 9272 is a selective, orally active and brain penetrant mGluR5 antagonist with IC50s of 2.6 nM and 7.6 nM for rat and human receptors, respectively. AZD 9272 shows >3900-fold selectivity over other mGlu receptors[1]2].

Product Specifications

CAS Number

[327056-26-8]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/AZD_9272.html

Purity

99.87

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N#CC1=CC(F)=CC(C2=NC(C3=CC=C(F)C=N3)=NO2)=C1

Molecular Formula

C14H6F2N4O

Molecular Weight

284.22

References & Citations

[1]Swedberg MD, et al. AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects. J Pharmacol Exp Ther. 2014 Aug;350 (2) :212-22.|[2]Raboisson P, et al. Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development. Bioorg Med Chem Lett. 2012 Nov 15;22 (22) :6974-9.