Human ADSL Protein (Highly Pure)

<strong>Human ADSL Protein (Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2011536_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 1 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20℃_x000D_ <strong>Keywords:</strong> ADSL protein (His tag), Recombinant human ADSL protein (His tag), ASL protein, Adenylosuccinate lyase protein, AMPS protein, ASASE protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Taha-Mehlitz S, Bianco G, Coto-Llerena M, Kancherla V, Bantug GR, Gallon J, Ercan C, Panebianco F, Eppenberger-Castori S, von Strauss M, Staubli S, Bolli M, Peterli R, Matter MS, Terracciano LM, von Flüe M, Ng CKY, Soysal SD, Kollmar O, Piscuoglio S. Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis Theranostics. 2021 Feb 15;11(9):4011-4029._x000D_ 2: Jurecka A, Zikanova M, Kmoch S, Tylki-Szymańska A. Adenylosuccinate lyase deficiency J Inherit Metab Dis. 2015 Mar;38(2):231-42._x000D_ 3: Kmoch S, Hartmannová H, Stibůrková B, Krijt J, Zikánová M, Sebesta I. Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length cDNA and its isoform, gene structure and molecular basis for ADSL deficiency in six patients Hum Mol Genet. 2000 Jun 12;9(10):1501-13._x000D_ 4: Dutto I, Gerhards J, Herrera A, Souckova O, Škopová V, Smak JA, Junza A, Yanes O, Boeckx C, Burkhalter MD, Zikánová M, Pons S, Philipp M, Lüders J, Stracker TH. Pathway-specific effects of ADSL deficiency on neurodevelopment Elife. 2022 Feb 8;11:e70518._x000D_ 5: Van Laer B, Kapp U, Soler-Lopez M, Moczulska K, Pääbo S, Leonard G, Mueller-Dieckmann C. Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase Sci Rep. 2018 Dec 20;8(1):18008._x000D_ 6: Spiegel EK, Colman RF, Patterson D. Adenylosuccinate lyase deficiency Mol Genet Metab. 2006 Sep-Oct;89(1-2):19-31._x000D_ 7: Zurlo G, Liu X, Takada M, Fan C, Simon JM, Ptacek TS, Rodriguez J, von Kriegsheim A, Liu J, Locasale JW, Robinson A, Zhang J, Holler JM, Kim B, Zikánová M, Bierau J, Xie L, Chen X, Li M, Perou CM, Zhang Q. Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer Nat Commun. 2019 Nov 15;10(1):5177._x000D_ 8: Park H, Ohshima K, Nojima S, Tahara S, Kurashige M, Hori Y, Okuzaki D, Wada N, Ikeda JI, Morii E. Adenylosuccinate lyase enhances aggressiveness of endometrial cancer by increasing killer cell lectin-like receptor C3 expression by fumarate Lab Invest. 2018 Apr;98(4):449-461._x000D_ 9: Baresova V, Skopova V, Sikora J, Patterson D, Sovova J, Zikanova M, Kmoch S. Mutations of ATIC and ADSL affect purinosome assembly in cultured skin fibroblasts from patients with AICA-ribosiduria and ADSL deficiency Hum Mol Genet. 2012 Apr 1;21(7):1534-43._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/20127976">10: Zikanova M, Skopova V, Hnizda A, Krijt J, Kmoch S. Biochemical and structural analysis of 14 mutant adsl enzyme complexes and correlation to phenotypic heterogeneity of adenylosuccinate lyase deficiency Hum Mutat. 2010 Apr;31(4):445-55. </a>_x000D_ _x000D_ <strong>Products Related to Human ADSL Protein (Highly Pure) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>