CUR61414
Product Specifications
Product Name Alternative
CC 122,CC 122 (hydrochloride)
UNSPSC Description
CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC50?=100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a Ki? value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells[1][2].
Target Antigen
Apoptosis; Hedgehog; Smo
Type
Reference compound
Related Pathways
Apoptosis;Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cur61414.html
Purity
99.04
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(C)CC(N([C@@H]1CN(CC2=CC=C(OCO3)C3=C2)[C@H](C(N4CCNCC4)=O)C1)CC5=CC=CC(OC)=C5)=O
Molecular Weight
550.69
References & Citations
[1]Williams JA, et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21. Epub 2003 Apr 4.|[2]Frank-Kamenetsky M, et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.J Biol. 2002 Nov 6;1(2):10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113965/CUR61414-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113965/CUR61414-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
334998-36-6
Available Sizes
Curated Selection
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