Mequinol

Mequinol (4-Methoxyphenol) yes MercurialisOne of the bioactive ingredients, mainly used for skin discoloration[1]. MequinolIs an antioxidant that has additive/synergistic effects on carcinogenesis when combined with other phenolic antioxidants. Mequinolalso promote hERαDependent chaperone production with potential estrogenic activity[1][2][3].

Product Specifications

CAS Number

[150-76-5]

Product Name Alternative

P-Hydroxyanisole

UNSPSC

12352005

Hazard Statement

H302, H317, H319, H361, H401, H412

Target

Estrogen Receptor/ERR; HSP

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/mequinol.html

Purity

99.98

Solubility

DMSO : ≥ 100 mg/mL|H2O : ≥ 100 mg/mL

Smiles

OC(C=C1)=CC=C1OC

Molecular Formula

C7H8O2

Molecular Weight

124.14

Precautions

H302, H317, H319, H361, H401, H412

References & Citations

[1]Callender VD, et al. Postinflammatory hyperpigmentation: etiologic and therapeutic considerations. Am J Clin Dermatol. 2011 Apr 1;12 (2) :87-99.|[2]Kita K, et al. Increase in the levels of chaperone proteins by exposure to beta-estradiol, bisphenol A and 4-methoxyphenol in human cells transfected with estrogen receptor alpha cDNA. Toxicol In Vitro. 2009 Jun;23 (4) :728-35.|[3]Hirose M, et al. Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi-organ carcinogenesis model. Carcinogenesis. 1998 Jan;19 (1) :207-12.