Dabogratinib
Dabogratinib is an orally active, selective inhibitor for FGFR3 with an IC50 of 11 nM in Ba/F3. Dabogratinib exhibits antitumor efficacy against urothelial cancers and solid tumors[1].
Product Specifications
CAS Number
[2800223-30-5]
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tyra-300.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(N(C1)CC1(C2)CN2C(N=C3)=CC=C3C4=NNC5=CC=C(O[C@H](C)C6=C(Cl)C=NC=C6Cl)C=C54)(C)=O
Molecular Formula
C25H24Cl2N6O3S
Molecular Weight
559.47
References & Citations
[1]Hudkins RL, et al., Discovery of TYRA-300: First Oral Selective FGFR3 Inhibitor for the Treatment of Urothelial Cancers and Achondroplasia. J Med Chem. 2024 Sep 26;67 (18) :16737-16756.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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