AICAR
AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR is also an autophagy, YAP and mitophagy inhibitor. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR inhibits autophagy through a mechanism independent of AMPK activity[1][2][6].
Product Specifications
CAS Number
[2627-69-2]
Product Name Alternative
Acadesine; AICA Riboside
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
AMPK; Autophagy; Endogenous Metabolite; Mitophagy; YAP
Type
Reference compound
Related Pathways
Autophagy; Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AICAR.html
Purity
99.99
Solubility
DMSO : 116.67 mg/mL (ultrasonic) |H2O : 65 mg/mL (ultrasonic; warming)
Smiles
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N)=C(N=C2)C(N)=O)O1
Molecular Formula
C9H14N4O5
Molecular Weight
258.23
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
AMPK; Human Endogenous Metabolite
Citation 01
Available Sizes
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