Chlorogenic acid

Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound[1][2][3].

Product Specifications

CAS Number

[327-97-9]

Product Name Alternative

3-O-Caffeoylquinic acid; Heriguard; NSC-407296

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Endogenous Metabolite; HIF/HIF Prolyl-Hydroxylase; Influenza Virus; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Chlorogenic-acid.html

Concentration

10mM

Purity

99.55

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C([C@@]1(O)C[C@@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)[C@H](O)[C@H](O)C1)O

Molecular Formula

C16H18O9

Molecular Weight

354.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Park JJ, et al. Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1α/AKT pathway. Cell Oncol (Dordr) . 2015 Jan 6.|[2]Park SH, et al. IRAK4 as a Molecular Target in the Amelioration of Innate Immunity-Related Endotoxic Shock and Acute Liver Injury by Chlorogenic Acid. J Immunol. 2015 Feb 1;194 (3) :1122-30.|[3]Kang JW, et al. Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats. Biomol Ther (Seoul) . 2014 Sep;22 (5) :420-5.|[4]Huang S, et al. Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation. Theranostics. 2019 Sep 19;9 (23) :6745-6763.