UNC4203
UNC4203 is a potent, orally available and highly selective MERTK inhibitor, with IC50s of 1.2 nM, 140 nM, 42 nM and 90 nM for MERTK, AXL, TYRO3 and FLT3, respectively[1].
Product Specifications
CAS Number
[1818234-19-3]
UNSPSC
12352005
Target
FLT3; TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc4203.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@@H]1CC[C@H](CC1)N2C=C(C3=CN=C(N=C32)N[C@@H](C)CCC)C4=CC=C(C=C4)CN5CCN(CCC5)C
Molecular Formula
C30H44N6O
Molecular Weight
504.71
References & Citations
[1]Hongchao Zheng, et al. UNC5293, a potent, orally available and highly MERTK-selective inhibitor. Eur J Med Chem. 2021 Aug 5;220:113534.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl; Tyro3
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
