Isonicotinic acid

Isonicotinic acid is an Isoniazid (HY-B0329) metabolite. The Isonicotinic acid derivative Enisamium inhibits the replication of multiple subtypes of influenza A virus[1][2].

Product Specifications

CAS Number

[55-22-1]

UNSPSC

12352005

Hazard Statement

H319

Target

Drug Intermediate; Drug Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/isonicotinic-acid.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C1=CC=NC=C1

Molecular Formula

C6H5NO2

Molecular Weight

123.11

Precautions

H319

References & Citations

[1]Seng KY, et al. Population pharmacokinetic analysis of isoniazid, acetylisoniazid, and isonicotinic acid in healthy volunteers. Antimicrob Agents Chemother. 2015 Nov;59 (11) :6791-9.|[2]Boltz D, et al. Activity of enisamium, an isonicotinic acid derivative, against influenza viruses in differentiated normal human bronchial epithelial cells. Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618811416.