SF2523
SF2523 is a highly selective and potent inhibitor of PI3K with IC50s of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.
Product Specifications
CAS Number
[1174428-47-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA-PK; Epigenetic Reader Domain; PI3K
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SF2523.html
Concentration
10mM
Purity
99.34
Solubility
DMSO : ≥ 30 mg/mL
Smiles
O=C1C=C(N2CCOCC2)OC3=C1SC=C3C4=CC=C(OCCO5)C5=C4
Molecular Formula
C19H17NO5S
Molecular Weight
371.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Carlino L, et al. Dual Kinase-Bromodomain Inhibitors in Anticancer Drug Discovery: A Structural andPharmacological Perspective. J Med Chem. 2016 Oct 27;59 (20) :9305-9320.|[2]Andrews FH, et al. Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis. Proc Natl Acad Sci U S A. 2017 Feb 14;114 (7) :E1072-E1080.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; PI3Kα; PI3Kγ
Available Sizes
Curated Selection
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