Nur77 modulator 3
Nur77 modulator 3 is a Nur77 modulator. Nur77 modulator 3 induces Nur77 expression, inhibits hepatic stellate cells (HSCs) activation, and reduces extracellular matrix (ECM) deposition. Nur77 modulator 3 enhances Nur77-denpendent autophagic flux and significantly inhibits the mTORC1 signaling pathway. Nur77 modulator 3 ameliorates HSCs activation, inflammation and hepatic fibrosis in vivo[1].
Product Specifications
CAS Number
[2097787-75-0]
UNSPSC
12352005
Target
Atg8/LC3; Autophagy; mTOR; Nuclear Hormone Receptor 4A/NR4A; p62; TGF-beta/Smad
Type
Reference compound
Related Pathways
Autophagy; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Neurological Disease; Inflammation/Immunology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nur77-modulator-3.html
Purity
99.01
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
S=C(N/N=C/C1=CNC2=CC=CC=C12)NC3=CC=C(C)C=C3
Molecular Formula
C17H16N4S
Molecular Weight
308.40
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTORC1; Nur77/NR4A1
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
CLDND1, ID (CLDND1, C3orf4, Claudin domain-containing protein 1, Membrane protein GENX-3745) (AP) discontinued
DUT (Deoxyuridine 5'-triphosphate Nucleotidohydrolase, Mitochondrial, dUTPase, dUTP Pyrophosphatase) (MaxLight 650)
DUT (Deoxyuridine 5'-triphosphate Nucleotidohydrolase, Mitochondrial, dUTPase, dUTP Pyrophosphatase) (MaxLight 650)