Demethoxycurcumin

Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research[1][2][3][4][5].

Product Specifications

CAS Number

[22608-11-3]

Product Name Alternative

Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin

UNSPSC

12352005

Hazard Statement

H400

Target

Apoptosis; Bacterial; Cholinesterase (ChE) ; NO Synthase

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Demethoxycurcumin.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CC(/C=C/C1=CC=C(O)C=C1)=O)/C=C/C2=CC=C(O)C(OC)=C2

Molecular Formula

C20H18O5

Molecular Weight

338.36

Precautions

H400

References & Citations

[1]Somchit M, et al. Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model. Asian Pac J Cancer Prev. 2014;15 (4) :1807-10.|[2]Ko YC, et al. Demethoxycurcumin Alters Gene Expression Associated with DNA Damage, Cell Cycle and Apoptosis in Human Lung Cancer NCI-H460 Cells In Vitro. In Vivo. 2015 01-02;29 (1) :83-94.|[3]Ahmed T, et al. A comparative study of curcuminoids to measure their effect on inflammatory and apoptotic gene expression in an Aβ plus ibotenic acid-infused rat model of Alzheimer's disease. Brain Res. 2011 Jul 11;1400:1-18. |[4]Lim DW, et al. Enhanced Cognitive Effects of Demethoxycurcumin, a Natural Derivative of Curcumin on Scopolamine-Induced Memory Impairment in Mice. Molecules. 2016 Aug 5;21 (8) :1022. |[5]Luo J, et al. Demethoxycurcumin: A potential antimicrobial agent: Exposure by microcalorimetry and modified broth microdilution method[J]. Journal of Thermal Analysis and Calorimetry, 2014, 115: 2331-2338.