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Triapine (hydrochloride)

Triapine (hydrochloride) is the hydrochloride form of Triapine (HY-10082) . Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer[1].

Product Specifications

CAS Number

[216240-62-9]

Product Name Alternative

3-AP (hydrochloride) ; PAN-811 (hydrochloride) ; OCX191 (hydrochloride)

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/triapine-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

S=C(N)N/N=C/C1=NC=CC=C1N.[H]Cl

Molecular Formula

C7H10ClN5S

Molecular Weight

231.71

References & Citations

[1]Martin LK, et al. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84 (4) :e475-81.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 3

Curated Selection

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