PNR-7-02
Product Specifications
UNSPSC Description
PNR-7-02 inhibits Pol η function with an IC50 value of near 8 μM, which binds to the little finger domain. PNR-7-02 is also an inhibitor against hRev1 and hpol lambda (λ). PNR-7-02 acts synergistically with Cisplatin (HY-17394) to kill chronic myeloid leukaemia and ovarian cancer cell lines. PNR-7-02 is an indole thio-barbituric acid (ITBA) derivative with both N-napthoyl moiety and 5-chloro substituent on the indole ring[1][2].
Target Antigen
Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pnr-7-02.html
Smiles
O=C1NC(NC(/C1=C\C2=CN(CC3=CC4=C(C=CC=C4)C=C3)C5=C2C=C(Cl)C=C5)=O)=S
Molecular Weight
445.92
References & Citations
[1]Zafar M K, et al. Investigation of Structure‐Activity Relationships for Small‐Molecule Inhibitors of Human DNA Polymerase Eta[J]. The FASEB Journal, 2016, 30: 1052.3-1052.3.|[2]Ler AAL, et al. DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target. Front Oncol. 2022 Feb 7;11:822500.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117664/PNR-7-02-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117664/
Clinical Information
No Development Reported
CAS Number
1633660-76-0
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
