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(2R)-Octyl-α-hydroxyglutarate-d17

Product Specifications

UNSPSC Description

(2R)-Octyl-α-hydroxyglutarate-d17 ((2R)-Octyl-2-HG-d17) is deuterium labeled (2S)-Octyl-α-hydroxyglutarate. (2S)-Octyl-α-hydroxyglutarate ((2S)-Octyl-2-HG) is a modified form of S-isomer 2-Hydroxyglutarate[1].

Target Antigen

Isotope-Labeled Compounds; Others

Type

Isotope-Labeled Compounds

Related Pathways

Others

Field of Research

Cancer

Smiles

OC(CC[C@H](C(OC([2H])(C([2H])(C([2H])(C([2H])(C([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])[2H])[2H])[2H])[2H])=O)O)=O

Molecular Weight

277.43

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Sulkowski PL, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologousrecombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb 1;9(375).